Both have good outcome data. But, not all statins are the same. Monitor closely. Millions of people must consider whether the potential benefits outweigh the risk of this side effect. Having too much cholesterol in your blood increases your risk of heart attacks and strokes. Do all statins cause leg pain? Lovastatin (Mevacor ®) 40 mg . Both are safe. For atorvastatin and simvastatin the starting dose is 10 mg daily. Learn about alternatives such as … Renal dosing: In severe dysfunction, start only if patient tolerates 5 mg daily of simvastatin. Usual initial dose: Ezetimibe 10 mg and simvastatin 20 mg once daily in the evening. Fluvastatin (Lescol ®) 80 mg . Both are safe. Statins include atorvastatin (Lipitor), fluvastatin (Lescol XL), lovastatin (Altoprev), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor, Ezallor) and simvastatin (Zocor, FloLipid). However, they can have side effects and might not be right for everyone. These potentially life-saving medications have some important medical uses, but the downside is that they could also cause muscle pain or muscle cramps—also known as statin-induced muscle pain. Maintenance doses The table below gives important dose restrictions for atorvastatin and simvastatin when used in … Pravastatin 1 (Pravachol ®) 40 mg . Compare Atorvastatin vs Simvastatin head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Patients who require >55% reduction in LDL-C: Initial: Ezetimibe 10 mg and simvastatin 40 mg once daily. Very similar: Atorvastatin (lipitor) is a little more potent, milligram for milligram than Simvastatin (zocor). Approximate Equivalent Dose 2 . Atorvastatin rated 4.4/10 vs Simvastatin rated 5.0/10 in overall patient satisfaction. Both have good outcome data. All statins can result in muscle pain. Unfortunately, some people find that they cannot tolerate any statins. 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