General tariff:20.0%. . ; Perrigo, B., A practical gas chromatographic screening procedure for toxicological analysis, Can.Soc.Forens.Sci.J., 9(2), 1975, 69-74. ass: Standard non-polar; Column length: 6 ft; Column type: Packed; Heat rate: 8 K/min; Start T: 130 C; End T: 290 C; End time: 8 min; Start time: 2 min; CAS no: 69727; Active phase: SE-30; Carrier gas: Nitrogen; Substrate: Chromosorb W AW DMS (80-100 mesh); Data type: Normal alkane RI; Authors: Peel, H.W. It has the formula C7H6O3. Nixon M, et al. You can also browse global suppliers,vendor,prices,Price,manufacturers of Salicylic acid(69-72-7). About Us | Water solubility increased by Na3PO4, alkali acetates or alkali citrates, White to faint yellow crystalline powder; faint nutty odour. P280-P301 + P312 + P330-P305 + P351 + P338 + P310. Untersuchungen mit dem destillierten Wasser der Blüthen von, "Salicylic Acid, a multifaceted hormone to combat disease", "Induction by Salicylic Acid of Pathogenesis-related Proteins or Resistance to Alfalfa Mosaic Virus Infection in Various Plant Species", International Chemical Safety Cards | CDC/NIOSH, https://en.wikipedia.org/w/index.php?title=Salicylic_acid&oldid=982904933, World Health Organization essential medicines, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License. Physical Properties: Melting Point : 158-161 ºC. ; Target: Cyclooxygenase?COX? Salicylic Acid. However, when the same experiments are performed using 30 μM arachidonic acid, Salicylic acid is an ineffective inhibitor of COX-2 activity, with an apparent IC50 value of more than 100 μg/mL, and achieves a maximal inhibition of less than 50%[1]. : Scribe Publications. The melting point is, along with the boiling point, a characteristic property of every substance. Salicylic acid is used as a food preservative, a bactericidal and an antiseptic.[15]. Furthermore, there is a trend to reduce plasma triglyceride levels after Salicylic acid treatment in C57Bl/6 DIO mice (P=0.059). Solubility: Water and Organic Solvents. Hematin is first dissolved in a concentrated stock of 100 mM in 1 M NaOH before being further diluted in Tris buffer. Visit BYJU'S to understand the properties, structure and uses of Salicylic Acid (C7H6O3) explained by India's best teachers. [10] As such, it is used to treat warts, psoriasis, acne, ringworm, dandruff, and ichthyosis. We here report synthesis for the first time of the acetyl salicylic acid dimer 5,5'-methylenebis(2-acetoxybenzoic acid) (DAS). Product Classification | When added together with IL-1β for 24 hr, Salicylic acid causes a concentration-dependent inhibition of PGE2 release with an apparent IC50 value of approximately 5 μg/mL. [20], Salicylic acid has the formula C6H4(OH)COOH, where the OH group is ortho to the carboxyl group. CopyCopied, Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, Predicted data is generated using the US Environmental Protection Agency’s EPISuite™, Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the. Because instead of forming a hydroxyl group in salicylic acid, acetylsalicylic acid forms an ether of acetate. Safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles. ; Polissiou, M., Flavour compounds of Greek cotton honey, J. Sci. A colorless, crystalline organic carboxylic acid. [1]. Salicylate may competitively inhibit prostaglandin formation. CopyCopied, CSID:331, http://www.chemspider.com/Chemical-Structure.331.html (accessed 05:38, Nov 12, 2020) Chromatogr., 436, 1988, 137-172. ass: Standard non-polar; Column length: 1.8 m; Column type: Packed; Heat rate: 8 K/min; Start T: 130 C; End T: 290 C; End time: 8 min; Start time: 2 min; CAS no: 69727; Active phase: SE-30; Carrier gas: N2; Substrate: Chromosorb W; Data type: Linear RI; Authors: Perrigo, B.J. Enzyme reactions are carried out in individual wells of 96-well plates with a final reaction volume of 200 μL. [36], Salicylic acid is a phenolic phytohormone and is found in plants with roles in plant growth and development, photosynthesis, transpiration, ion uptake and transport. Diabetes. Melting point −8.6 °C (16.5 °F; 264.5 K) Boiling point: 222 °C (432 °F; 495 K) Decomposes at 340–350 °C Inhibition of aberrant complement activation by a dimer of acetylsalicylic acid. The plates are incubated at 37° for 30 min before Arachidonic acid (10 nM to 30 μM) is added for a further 15 min. ; Tsypyshev, O.Yu., Gas chromatographic determination of the products of the synthesis of chlorine-substituted salicylic acids, Zh. The ability of Salicylic acid to directly inhibit COX-2 activity in A549 cells is tested after a 30-min exposure period, followed by the addition of different concentrations of exogenous arachidonic acid (1, 10, and 30 μM). It is obtained from the bark of the white willow and wintergreen leaves. Tax rebate rate:9.0%. MSDS/SDS Database Search | Graphene modified glassy carbon sensor for the determination of aspirin metabolites in human biological samples. Substances to be avoided include oxidizing agents, strong bases, iodine, fluorine. Find chemicals information Salicylic acid at guidechem, professional and easy to use. Sodium salicylate is commercially prepared by treating sodium phenolate (the sodium salt of phenol) with carbon dioxide at high pressure (100 atm) and high temperature (115°C) – a method known as the Kolbe-Schmitt reaction. Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid. ; Hua, R.L. Formula Weight: 138.12. Salicylic acid is an effective inhibitor of COX-2 activity at concentrations far below those required to inhibit NF-κB (20 mg/mL) activation. [31] Raffaele Piria, an Italian chemist, was able to convert the substance into a sugar and a second component, which on oxidation becomes salicylic acid.[32][33]. 2012 Apr;61(4):790-6. [18] Even for wart removal, such a solution should be applied once or twice a day – more frequent use may lead to an increase in side-effects without an increase in efficacy. Mol Pharmacol. Shanghai Jizhi Biochemical Technology Co., Ltd. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation. 2012 Apr;61(4):790-6. Sodium salicylate is a useful phosphor in the vacuum ultraviolet spectral range, with nearly flat quantum efficiency for wavelengths between 10 and 100 nm. Aspirin (acetylsalicylic acid or ASA) can be prepared by the esterification of the phenolic hydroxyl group of salicylic acid with the acetyl group from acetic anhydride or acetyl chloride. [16] It fluoresces in the blue at 420 nm. Mol Pharmacol. ; Ding, S.F. Several studies suggest that humans metabolize salicylic acid in measurable quantities from these plants. Salicylic acid significantly reduces 11β-HSD1 mRNA in omental adipose tissue in C57Bl/6 DIO mice, with a similar trend in mesenteric adipose (P=0.057). The systematic IUPAC name of this compound is 2-hydroxybenzoic acid. In contrast, when exogenous arachidonic acid is increased to 30 μM, Salicylic acid is a very weak inhibitor of COX-2 activity with an IC50 of >100 μg/mL. CopyCopied, InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10) It is easily prepared on a clean surface by spraying a saturated solution of the salt in methanol followed by evaporation. Anal. 3.57377: 1126.012-212.625: Stull, 1947: Coefficents calculated by NIST from author's data. VAT:17.0%. It also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to the phenolic acceptor. Articles of Salicylic acid are included as well. Salicylic acid Guidechem provides Salicylic acid chemical database query, including CAS registy number 69-72-7, Salicylic acid MSDS (Material Safety Data Sheet), nature, English name, manufacturer, function/use, molecular weight, density, boiling point, melting point, structural formula, etc. MFN tariff:6.5%. Journals | Nixon M, et al. Chromatogr., 220, 1981, 195-252. ass: Standard non-polar; Column length: 6 ft; Column type: Packed; Heat rate: 8 K/min; Start T: 130 C; End T: 290 C; End time: 8 min; Start time: 2 min; CAS no: 69727; Active phase: SE-30; Carrier gas: N2; Substrate: Chromosorb W AW DMS; Data type: Normal alkane RI; Authors: Peel, H.W. Refractive Index : n/a. Salicylic acid is used in the production of other pharmaceuticals, including 4-aminosalicylic acid, sandulpiride, and landetimide (via Salethamide). Chamowitz, D. (2017). More soluble in boiling water. It is poorly soluble in water (2 g/L at 20 °C).[21]. Salicylic acid acutely (30 min) also causes a concentration-dependent inhibition of COX-2 activity measured in the presence of 0, 1, or 10 μM exogenous arachidonic acid. ... Boiling Point: 211 °C: Melting Point: 158.6 °C: Salicylic Acid structure – C 7 H 6 O 3. The salts and esters of salicylic acid are known as salicylates. Slightly soluble in cold water. Salicylic acid (from Latin salix, willow tree) is a lipophilic monohydroxybenzoic acid, a type of phenolic acid, and a beta hydroxy acid (BHA). Toxicol., 37, 1977, 295-305. ass: Standard non-polar; Column diameter: 0.2 mm; Column length: 20 m; Column type: Capillary; Heat rate: 4 K/min; Start T: 100 C; End T: 230 C; CAS no: 69727; Active phase: SE-30; Data type: Normal alkane RI; Authors: Shakirov, L.G. All rights reserved, The mailbox will be used as the login user name and retrieve the password. Visit ChemicalBook To find more Salicylic acid(69-72-7) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. Boiling Point (°C): 211. [24] It was used in Europe and China to treat these conditions. DAS inhibits aberrant complement activation by selectively blocking facto... A graphene modified glassy carbon (GR/GCE) sensor has been developed for the determination of aspirin metabolites 2,3- and 2,5-dihydroxybenzoic acids (2,3- and 2,5-DHB). Temperature (K) A B C Reference Comment; 386.8 - 529. It is also known as 2-hydroxybenzoic acid. [42], InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10), InChI=1/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10), Except where otherwise noted, data are given for materials in their.

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